The Most Comprehensive Microbiome Analysis. Built for Your Practice.

Jona uses deep shotgun metagenomic sequencing and stool chemistry biomarkers to give you an unmatched picture of your patients' microbiome. Easy integration, same-day approval.

BOOK INTRO CALL

Trusted by leading practitioners worldwide

How Jona’s Gut Microbiome Analysis Outperforms with Evidence-Backed Interpretation

The gold standard in microbiome sequencing

Jona's deep shotgun metagenomic sequencing is the most comprehensive testing method, extending far beyond PCR panels. Paired with clinical stool chemistry biomarkers, no other analysis delivers this detail.

Turn 220K+ studies into better patient outcomes

Jona AI analyzes millions of data points to identify clinically relevant microbiome patterns and disease-relevant health associations across all physiological systems, with Action Plans tailored to your patients.

Integrate the full breadth of microbiome science

Seamlessly integrated into your practice, Jona provides clinician-ready reporting and adapts to your existing workflow. Ongoing clinical education ensures Jona feels like a natural extension of your care.

Built for the complexity of the microbiome.

Diagnostic Solutions'GI Map
Genova'sGI Effects
Vibrant Wellness'Gut Zoomer
Tiny Health PRO
Vitract'sDeepGut™ Plus
Evidence-based disease detection & reporting Identifies microbiome-linked disease markers across all physiological systems
Personalized Action Plan to optimize health Precision microbiome data to make diet and lifestyle recommendations with confidence
Digital Twin simulation & interactive analysis Ecosystem-level simulations calculated from unique biological profiles
Deep shotgun metagenomic sequencing Most comprehensive sequencing method — identifies all organisms, down to the strain level
Pathogen & parasite detection Detection of potentially harmful organisms in the gut microbiome
Functional microbiome analysis Microbial production of SCFAs, histamine, methane, and more
Clinical stool biomarkers Calprotectin, secretory IgA, lactoferrin, fecal fats, pancreatic elastase, and more

Limited or partial coverage

Jona Advanced decodes how the microbiome impacts every physiological system.

Convenient integration into your workflow.

01

Create an account

Manage patient orders and results from the practitioner portal.

02

Customize your order flow

Get test kits shipped to your practice or directly to patients.

03

At-home sample collection

Patient mails stool sample directly to our CLIA-certified lab.

04

Review Analysis together

Get notified when Analysis is ready. Review it in under 5 minutes.

05

Free clinical education

Access to MDs for interpretation support and clinical education.

Liquid error (sections/aboutus-jona-partners line 100): invalid url input

Developed with the world's leaders in microbiome science.

Headshot of Dr. Eran Segal, PhD​

Eran Segal, PhD​

Professor of Computer Science at Weizmann Institute

Headshot of Willem De Vos, PhD​

Willem De Vos, PhD​

Emeritus Distinguished Professor at Wageningen University, Emeritus Professor of Human Microbiomics at University of Helsinki

Zain Kassam MD, MPH team member photo

Zain Kassam MD, MPH

Biotechnology entrepreneur and physician-scientist, Chief Medical Officer at Seed, Co-Founder & former Chief Medical Officer at Finch Therapeutics and OpenBiome

Kfir  Bar, PhD team member photo

Kfir Bar, PhD

AI Lead

Jessica Allegretti, MD, MPH team member photo

Jessica Allegretti, MD, MPH

Medical Director and Gastroenterologist at Crohn's and Colitis Center, Brigham and Women's Hospital. Associate Professor of Medicine, Harvard Medical School ​​

Jordan Axelrad, MD, MPH team member photo

Jordan Axelrad, MD, MPH

Director of Research in the Inflammatory Bowel Disease Center at NYU Langone Health. Associate Professor of Medicine in the Division of Gastroenterology, Department of Medicine, at NYU Grossman School of Medicine

Helen Messier, MD, PhD team member photo

Helen Messier, MD, PhD

Chief Medical and Science Officer at Fountain Life. Founded a national network of concierge medical practices in Canada. Served as the Medical Director of Genomics at Human Longevity Inc, and played a pivotal role as the inaugural Chief Medical Officer of Viome.

Sean Khozin, MD, MPH team member photo

Sean Khozin, MD, MPH

Physician-scientist and oncologist, Previously the CEO of CancerLinQ, senior leader at Johnson & Johnson, and founding member of the US FDA’s Oncology Center of Excellence

James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh team member photo

James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh

Internationally recognized clinical pharmacist, author, and board-certified clinical nutritionist, with over 40 years of clinical experience in natural products, lifestyle, drug/nutrient depletion, compounding pharmacy and peptides.

Andréanne Martin team member photo

Andréanne Martin

Leader in digestive health & microbiome, renowned speaker, founder of Epithelia clinic and Epithelia academy, her team of registered dietitians focused on GI, autoimmune and metabolic conditions

Headshot of Dr. Naresh Gunaratnam, M.D., AGAF

Naresh Gunaratnam, M.D., AGAF

Board certified Gastroenterologist, Staff Physician at Trinity Health, AGA Clinical Practice Counselor, President of the Digestive Health Physician Association (DHPA), Adjunct Clinical Instructor at the University of Michigan Medical School and Ross School of Business, Founder of Huron Gastro Wellness Program

Frequently Asked Questions

Jona goes beyond a narrow pathogen panel like most other tests. Unlike basic PCR methods, Jona uses deep shotgun metagenomic sequencing to identify, down to the strain level, all the bacteria, fungi, viruses, and other organisms in your patient's sample — usually leading to 10–20x more organisms detected than other tests.

Jona AI helps you interpret findings by identifying microbiome associations to conditions and symptoms based on 220K+ peer-reviewed studies. Using Digital Twin analysis, Jona simulates what actions your patient can take to improve their microbiome signatures — bringing the full breadth of microbiome science to your fingertips and saving you time.

Jona's Digital Twin models how dietary, lifestyle, and probiotic interventions may shift the microbiome — providing insight into potential outcomes before interventions are implemented.

Jona's customizable Action Plan allows you to set patient goals and tailor recommendations, so each patient receives a plan aligned with their clinical needs and health objectives.

Yes — Jona is HSA/FSA eligible with no Letter of Medical Necessity required. That means patients can access Jona instantly using their existing HSA or FSA funds — no extra steps, no delays, and no additional paperwork for your team.

The microbiome includes all organisms (bacteria, fungi, viruses, etc.) living in or on your body, playing a critical role in health, digestion, and aging.

Please schedule a call with our onboarding team by completing this brief survey. From here, our team will review your information and customize your Jona practitioner account.

Contact us at practices@jona.health with any questions.

Zonulin has been a valuable tool for opening up the gut permeability conversation — and the underlying concept is real. That said, it has measurement limitations even the literature acknowledges: levels fluctuate significantly day to day, and testing isn't standardized across labs, meaning the same patient can get very different results. It can signal something is off, but not what or why.

Instead, Jona measures markers that tell you what's actually happening in the gut: calprotectin (gut inflammation), secretory IgA and lactoferrin (immune response), and Short-Chain Fatty Acids (whether the gut lining is being protected). Most leaky gut protocols are exactly what Jona already recommends — just grounded in more reliable data.

more faqs